Browsing by Author "Gökhan-Kelekçi, Nesrin"
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Lipid peroxidation and osmotic fragility of red blood cells in sleep-apnea patients
Öztürk, Levent; Mansour, Bayat; Yüksel, Meral; Yılmaz, Ayşe Mine; Çelikoğlu, Seyhan I.; Gökhan-Kelekçi, Nesrin (Elsevier Science Bv, 2003)Background: Obstructive sleep apnea (OSA) refers to the occurrence of episodes of complete or partial pharyngeal obstruction with oxyhemoglobin desaturation during sleep. These hypoxia/reoxygenation episodes may cause ... -
New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors
Salgın-Göksen, Umut; Telli, Gökçen; Erikci, Açelya; Dedecengiz, Ezgi; Tel, Banu Cahide; Kaynak, F. Betül; Yelekçi, Kemal; Ücar, Gülberk; Gökhan-Kelekçi, Nesrin (AMER CHEMICAL SOC, 2021-02)Thirty compounds having 1-[2-(5-substituted-2-benzoxazolinone-3-yl) acetyl]-3,5-disubstitutedphenyl-2-pyrazoline structure and nine compounds having N'-(1,3-disubstitutedphenylallylidene)-2-(5-substituted- 2-benzoxazolin ... -
New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: Synthesis biological evaluation and structural determinants of MAO-A and MAO-B selectivity
Gökhan-Kelekçi, Nesrin; Koyunoğlu, Semra; Yabanoğlu-Çiftçi, Samiye; Yelekçi, Kemal; Özgen, Özen; Uçar, Gülberk; Erol, Kevser; Kendi, Engin; Yeşilada, Akguel (Pergamon-Elsevier Science Ltd, 2009)A new series of pyrazoline derivatives were prepared starting from a quinazolinone ring and evaluated for antidepressant anxiogenic and MAO-A and -B inhibitory activities by in vivo and in vitro tests respectively. Most ... -
Synthesis and molecular modeling of some novel hexahydroindazole derivatives as potent monoamine oxidase inhibitors
Gökhan-Kelekçi, Nesrin; Şimşek, O. Özgün; Ercan, Ayşe; Yelekçi, Kemal; Şahin, Z. Sibel; Işık, Şamil; Uçar, Gülberk; Bilgin, Abdullah Altan (Pergamon-Elsevier Science Ltd, 2009)A novel series of 2-thiocarbamoyl-234567-hexahydro-1H-indazole and 2-substituted thiocarbamoyl-33a 4567-hexahydro-2H-indazoles derivatives were synthesized and investigated for the ability to inhibit the activity of the A ...